Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phenol phytoalexin derived from grapes, berries, and other plants possessing a spectrum of pharmacologic properties. Resveratrol has been shown to modulate LDL levels, a major risk factor for cardiovascular disease, to interfere with or inhibit oncogenesis and tumor proliferation in in vivo animal cancer models and in human tumor cells in vitro , to significantly extend the lifespan of the yeast Saccharomyces cerevisiae , Caenorhabditis elegans and the fruit fly Drosophila melanogaster , and to produce wide-ranging benefits in animal models of obsesity and diabetes.Resveratrol has gained mainstream attention as the red wine pill, with widespread claims made of human health benefits that have outpaced the existing evidence. Over the past few years, many clinical trials have been conducted to evaluate the health effects of resveratrol in humans, in the treatment of cancer, cardiovascular disease, obesity, diabetes, osteopenia and osteoporosis, and others. Considerable work is also underway exploring the optimization of resveratrol delivery and bioavailability in nutraceutical and pharmaceutical paradigms. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org ). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

A pathway to community, growth, and change This collection of inclusive essays explores the role of debate in understanding and critiquing injustice and inequality. Edited by Shawn F. Briscoe, these essays closely examine multiple approaches to debate, considering their respective merits and controversies. This detailed compilation analyzes how debate methodologies are useful in everyday life and whether certain approaches have any value at all. Briscoe provides an in-depth look into the varying styles of debate and contributes to a greater understanding of argument theory by discussing three stylistic approaches: audience-centered, technical/progressive, and non-traditional/performative. The book demonstrates that all three approaches offer students opportunity to engage in a socioemotional learning space, a discipline that prepares students for undergraduate and graduate work, a study that prepares participants for future careers, and a field that investigates current controversies and how to tackle them. Briscoe offers compelling narratives from BIPOC, LGBTQIA, and women authors that explore the personal impact of debate on social equality within this academic discipline, our educational system, and society. The diversity in gender and race of the contributing authors allows for a multitude of perspectives on the complex styles, benefits, and issues discussed in Transcending the Game. Briscoe peels back the mystery that shrouds the benefits of academic, competitive debate from outsiders and insiders alike. A myriad of personal narratives tell stories about the role of debate in their lives; challenge the unproductive discourse in debate, education, and society; and offer diverse insight into why we debate. 

Handedness, or manual laterality of function, is thought to be both universal and unique to humans, making it a highly derived trait, based on an equally specialized neural substrate. By contrast, in various non-human species, both living and extinct, extent of lateralization varies. All known populations of living human beings apparently favor the right hand, motorically, culturally, and symbolically, thus right-handedness is species-typical, as well as species-specific. This laterality of function is correlated with asymmetry of structure, that is, neural, skeletal and muscular, for example as manifest especially in skilled movement, such as handwriting. Human brains are lop-sided, and sagitally-paired organs (hand, foot, eye, ear, etc.) are skewed in their use, usually biased to the right; explaining this variation appears to require both cultural and environmental causal variables. To tackle these questions and advance our knowledge of this basic human trait requires genuinely multi-disciplinary input by scholars willing to think inter-disciplinarily. Thus, participants in this Annals volume come from anthropology, archaeology, genetics, neurosciences, palaeo-anthropology, primatology, psychology, and psychiatry. NOTE: Annals volumes are available for sale as individual books or as a journal.

This "Annals" volume includes scholarly summaries of scientific achievement by winners and finalists candidates of the 2011 Prix Galien USA awards for achievement in pharmaceutical science. Contributions by GlaxoSmithKline, Amgen, Pfizer, and Janssen Biotech present advances in biotechnology and pharmaceutical agents that combat a range of diseases.

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ACADEMY MEMBERS: Please contact the New york Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Sciences receive full-text access to Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

This volume is the eleventh published from a conference sponsored by the World Organization for Specialized Studies on Diseases of the Esophagus (OESO) and the second to be published in Annals. As with the preceding publications, the present one follows a world conference of OESO; in this case, a conference entitled Reflux disease, from LES to UES, and beyond, held in Como, Italy. Collectively, the papers present the wealth of ideas and knowledge covered by the four-day OESO conference on esophagology, with each paper showcasing the responses provided by top experts to precise questions during the sessions of the conference. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

The behavioral and neurobiological connections between play and the development of critical cognitive functions, such as attention, remain largely unknown. We do not yet know how these connections relate to the formation of specific abilities, such as spatial ability, and to learning in formal environments, such as in the classroom. Insights into these issues would be beneficial not only for understanding play, attention, and learning individually, but also for the development of more efficacious systems for learning and for the treatment of neurodevelopmental disorders. This meeting report provides a synopsis of the conference "Play, Attention, and Learning: How Do Play and Timing Shape the Development of Attention and Facilitate Classroom Learning?," held on June 15, 2012 and presented by the New York Academy of Sciences and the Brain Trauma Foundation. The report outlines important research steps that need to be taken in order to address critical questions about play, human activity, and cognitive functions.

This volume presents reports from recent scientific meetings on topics in emerging fields: (1) Diabetes and Oral Disease: Implications for Health Professionals; (2) The New York Stem Cell Foundation: Sixth Annual Translational Stem Cell Research Conference; and (3) Chronic Inflammatory and Neuropathic Pain."Diabetes and Oral Disease: Implications for Health Professionals" was a one-day conference convened by the Columbia University College of Dental Medicine, the Columbia University College of Physicians and Surgeons, and the New York Academy of Sciences on May 4, 2011 at The New York Academy of Sciences in New York City. The program included an examination of the bidirectional relationship between oral disease and diabetes and the inter-professional working relationships for the care of people who have diabetes. The overall goal of the conference was to promote discussion among the healthcare professions who treat people with diabetes, encourage improved communication and collaboration among them and ultimately, improve patient management of the oral and overall effects of diabetes. Attracting over 150 members of the medical and dental professions from eight different countries, the conference included speakers from academia and government and was divided into four sessions. This report summarizes the scientific presentations of the event.

The New York Stem Cell Foundation's "Sixth Annual Translational Stem Cell Research Conference" convened on October 11-12, 2011 at The Rockefeller University in New York City. Over 450 scientists, patient advocates, and stem cell research supporters from 14 countries registered for the conference. In addition to poster and platform presentations, the conference featured panels entitled "Road to the Clinic" and "The Future of Regenerative Medicine."Sponsored by The New York Academy of Sciences, MedImmune, and Grunenthal Gmbh, "Chronic Inflammatory and Neuropathic Pain" was a two-day conference June 2-3, 2011 at the New York Academy of Sciences in New York City. Leading and emerging investigators studying the pathophysiological mechanisms underlying neuropathic and chronic pain, and experts in the clinical development of pain therapies came together at this forum to address novel issues, current challenges, and future directions of basic research in pain and pre-clinical and clinical development of new therapies for chronic pain. Presentations examined recent therapeutic breakthroughs based on small molecules; the emerging role of biologics as potential new therapies; and current challenges and potential solutions for improved translation of new pain therapies following early target identification, pre-clinical modeling, and clinical development.

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ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to "Annals" online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Evolutionary Dynamics and Information Hierarchies in Biological Systems: Aspen Center for Physics Workshop. Organisms use a variety of mechanisms to store, interpret, and use information that is organized in a large and complex hierarchy from DNA sequences, to chromatin regulation, to intra/extracellular signaling, to tissue/organ organization, to the interactions between organisms and species. This Annals volume presents individual papers and a summarizing meeting report stemming from a workshop at the Aspen Center for Physics in Aspen, Colorado, organized to discuss these issues. The three themed weeks of the workshop focused on the organization of DNA into chromatin, epigenetic adaptation and host/pathogen interaction, and macroevolution. Although these areas represent a wide breadth of biological phenomena, several unifying themes emerged through workshop discussions. In particular, the differences between the simplicity of our theoretical models and the complex interactions characteristic of real physical systems were repeatedly highlighted. Workshop discussions therefore pointed to key areas where theory and observations should aim to converge as we refine our understanding of evolution.

This volume presents two meeting reports from recent scientific conferences and a third paper of draft consensus guidelines for treating Shwachman-Diamond syndrome.

The first meeting report, "Advances in Bipolar Disorder: Selected Sessions from the International Conference on Bipolar Disorder," covers the 9th International Conference on Bipolar Disorder (ICBD) held in Pittsburgh, PA, June 9-11, 2011. The conference focused on a number of important issues concerning the diagnosis of bipolar disorders across the life span, advances in neuroscience, treatment strategies for bipolar disorders, early intervention, and medical comorbidity. This meeting report presents key points from the sessions including: strategies for moving biology forward; bipolar disorder and the forthcoming new DSM-5 nomenclature; management of bipolar disorders--both theory and intervention, with an emphasis on the medical comorbidities; and a review of several key task force reports commissioned by the International Society for Bipolar Disorder (ISBD).The second meeting report covers the Sixth International Congress on Shwachman-Diamond Syndrome (SDS), the only multidisciplinary forum devoted specifically to SDS, held at the New York Academy of Sciences June 28-30, 2011. SDS is an autosomal recessive genetic disorder involving multiple organ systems and affecting children and young adults. The meeting report explores the most important recent advances in our understanding of the clinical features, current management, and treatment of SDS, and the molecular function of SBDS in hematopoiesis, leukemogenesis, and organogenesis. The third paper in this volume presents draft consensus guidelines for diagnosis, evaluation, and treatment of Shwachman-Diamond syndrome. Evidence-based conclusions were made whenever possible. However, as in other rare diseases, the data are often anecdotal. Therefore, recommendations were also based upon the consensus of experienced clinicians from Canada, Europe, and the United States during and following an international SDS conference. New recommendations regarding diagnosis and management have been made reflecting advances in understanding the genetic basis and clinical manifestations of the disease.NOTE: "Annals" volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http: //ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632.

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This volume presents reports from three recent scientific meetings on special topics.

The first report discusses scientific perspectives on individuals' drive to consume, presented at the conference "The Interdisciplinary Science of Consumption: Mechanisms of Allocating Resources Across Disciplines" at the University of Michigan in May 2010. Sponsored by Rackham Graduate School and the Department of Psychology at the University of Michigan, the conference included presentations on human, primate, and rodent models and spanned multiple domains of consumption, including reward seeking, delay discounting, food-sharing reciprocity, and the consumption and display of material possessions across the life span.

The next report comes from the one-day symposium by the Centre for Immunity, Infection, and Evolution (CIIE) entitled "Wild Immunology," held at the University of Edinburgh, UK in June 2011. Funded by the Wellcome Trust, the CIIE aims to connect evolutionary biology and ecology with research in immunology and infectious diseases in order to gain an interdisciplinary perspective on challenges to global health. The central question of the symposium was "Why should we try to understand infection and immunity in wild systems?" Specifically, presenters explored how the immune response operates in the wild and how multiple coinfections and commensalism affect immune responses and host health in these wild systems. The symposium brought together a broad program of speakers, ranging from laboratory immunologists to infectious disease ecologists, working on wild birds, feral animals, wild and laboratory rodents, and on questions ranging from the dynamics of coinfection to how commensal bacteria affect the development of the immune system.

The final report discusses the work presented at "Advancing Drug Discovery for Schizophrenia," a conference sponsored by the New York Academy of Sciences and with support from the National Institute of Mental Health, the Life Technologies Foundation, and the Josiah Macy Jr. Foundation. The meeting, at the New York Academy of Sciences in March of 2011, included individual talks and panel discussions and highlighted basic, clinical, and translational research approaches, all of which contribute to the overarching goal of enhancing the pharmaceutical armamentarium for treating schizophrenia. The meeting report surveys work by the vanguard of schizophrenia research in such topics as genetic and epigenetic approaches, small molecule therapeutics, and the relationships between target genes, neuronal function, and symptoms of schizophrenia.

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ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to "Annals" online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

The changemaker's guide to catalyzing environmental behaviour change for a healthy future To tackle our urgent environmental problems and achieve positive, durable change, we must design solutions based directly on how people think, make decisions, and act. From hotels that save water and money using simple signage, to energy suppliers that boost participation in renewable energy programs through mere enrollment form tweaks—shifting the behavior of millions for the better is possible. Based on decades of research into what drives behavior change, Making Shift Happen provides a suite of powerful tools to transform the world. It features A to Z guidance on how to design a behavior change initiative—from choosing the right audience and uncovering what drives their behavior, to designing, prototyping, testing, and implementation. Clear instructions and real-world examples empower you to apply hundreds of behavioral science solutions including: Using social norms to spread positive environmental behaviors Selecting and testing stories, metaphors, and values to frame information for each audience Catalyzing action by aligning your initiative with your audience's personal and social motivators Breaking bad habits and building positive ones Capturing your audience's attention and reducing barriers to action Connecting people with nature and building empathy for the environment and its inhabitants. Making Shift Happen is a must-have guide for practitioners in non-profits, governments, and businesses looking to design successful campaigns and initiatives that shift behaviors and mindsets toward positive environmental outcomes and a better future for all. AWARDS GOLD | 2023 Nautilus Book Awards | Social Sciences & Education

Climate change is already beginning to affect New York State and these impacts are projected to grow. At the same time, the state has the ability to develop adaptation strategies that will address many climate-related risks, thereby reducing impacts and taking advantage of possible opportunities. The ClimAID assessment presented in this volume provides information on climate change impacts and adaptation for eight sectors in New York State: water resources, coastal zones, ecosystems, agriculture, energy, transportation, telecommunications, and public health. Observed climate trends and future climate projections were developed for seven regions across the state. Within each of the sectors, climate risks, vulnerabilities, and adaptation strategies are identified. Integrating themes across all of the sectors are equity and environmental justice and economics. Case studies are used to examine specific vulnerabilities and potential adaptation strategies in each of the eight sectors. These case studies also illustrate the linkages among climate vulnerabilities, risks, and adaptation, and demonstrate specific monitoring needs. Stakeholder participation was critical to the ClimAID assessment process to ensure relevance to decision makers across the state.

NOTE: "Annals" volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http: //ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to "Annals" online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.